Early-onset sepsis (EOS) is a worldwide major cause of morbidity and mortality especially in developing countries. The objectifs of our studie is to estimate the frequency of EOS, explore the different risk factors, the clinical features, the hematological; inflammatory and bacteriological parameters necessary for diagnosis, different causative organisms and ATB susceptibility in EOS. A 10-year retrospective study was used, including 153 cases that met the inclusion criteria. Among the 8908 admissions in NICU, sepsis occurred in 2,28% of cases. The sex ratio was 2,1 (Male: 62%, Female: 38%). Chorioamnionitis occurred in 13,7% of cases, PPROM in 44,4%. Intrapartum fever was found in 7% of cases, and amniotic fluid abnormalities in 36,6%. In neonatal risk factors we found prematurity in 76,15% of cases and VLBW in 21,56%. Respiratory distress was the most common symptom at admission with 66,1%. Bacteriological exam showed a positive Blood culture in 19,6% (30) of cases. The most common organisms isolated were E. coli in 16 cases, Group B streptococcus in 11 cases, and a positive LP in only 1 case isolating E. coli. All patients admitted to the NICU suspected of sepsis had a triple antibiotherapy. In our study, sepsis was responsible for 46,4% of deaths out of which 15 died at the first day of admission. Neonatal sepsis is associated with high rate of neonatal mortality. Poor antenatal care, absence of pregnancies follow-up, prematurity and very low birth weight are risk factors associated with EOS. In order to decrease EOS incidence and improve outcome for neonates, a contribution between Neonatologists and Obstetricians is a must.
| Published in | American Journal of Pediatrics (Volume 10, Issue 1) |
| DOI | 10.11648/j.ajp.20241001.16 |
| Page(s) | 34-40 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Neonatology, Early-Onset Sepsis, Risk Factors, Biomarker, Antibiotherapy
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APA Style
Dahou, M., Lehlimi, M., Korchi, Z., Chaini, R., Badre, A., et al. (2024). Early-Onset Neonatal Sepsis: The Challenges of Management. American Journal of Pediatrics, 10(1), 34-40. https://doi.org/10.11648/j.ajp.20241001.16
ACS Style
Dahou, M.; Lehlimi, M.; Korchi, Z.; Chaini, R.; Badre, A., et al. Early-Onset Neonatal Sepsis: The Challenges of Management. Am. J. Pediatr. 2024, 10(1), 34-40. doi: 10.11648/j.ajp.20241001.16
AMA Style
Dahou M, Lehlimi M, Korchi Z, Chaini R, Badre A, et al. Early-Onset Neonatal Sepsis: The Challenges of Management. Am J Pediatr. 2024;10(1):34-40. doi: 10.11648/j.ajp.20241001.16
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Download@article{10.11648/j.ajp.20241001.16,
author = {Meryem Dahou and Mouna Lehlimi and Zineb Korchi and Rabiaa Chaini and Amal Badre and Mounir Chemsi and Abdelahk Habzi},
title = {Early-Onset Neonatal Sepsis: The Challenges of Management},
journal = {American Journal of Pediatrics},
volume = {10},
number = {1},
pages = {34-40},
doi = {10.11648/j.ajp.20241001.16},
url = {https://doi.org/10.11648/j.ajp.20241001.16},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20241001.16},
abstract = {Early-onset sepsis (EOS) is a worldwide major cause of morbidity and mortality especially in developing countries. The objectifs of our studie is to estimate the frequency of EOS, explore the different risk factors, the clinical features, the hematological; inflammatory and bacteriological parameters necessary for diagnosis, different causative organisms and ATB susceptibility in EOS. A 10-year retrospective study was used, including 153 cases that met the inclusion criteria. Among the 8908 admissions in NICU, sepsis occurred in 2,28% of cases. The sex ratio was 2,1 (Male: 62%, Female: 38%). Chorioamnionitis occurred in 13,7% of cases, PPROM in 44,4%. Intrapartum fever was found in 7% of cases, and amniotic fluid abnormalities in 36,6%. In neonatal risk factors we found prematurity in 76,15% of cases and VLBW in 21,56%. Respiratory distress was the most common symptom at admission with 66,1%. Bacteriological exam showed a positive Blood culture in 19,6% (30) of cases. The most common organisms isolated were E. coli in 16 cases, Group B streptococcus in 11 cases, and a positive LP in only 1 case isolating E. coli. All patients admitted to the NICU suspected of sepsis had a triple antibiotherapy. In our study, sepsis was responsible for 46,4% of deaths out of which 15 died at the first day of admission. Neonatal sepsis is associated with high rate of neonatal mortality. Poor antenatal care, absence of pregnancies follow-up, prematurity and very low birth weight are risk factors associated with EOS. In order to decrease EOS incidence and improve outcome for neonates, a contribution between Neonatologists and Obstetricians is a must.},
year = {2024}
}
TY - JOUR T1 - Early-Onset Neonatal Sepsis: The Challenges of Management AU - Meryem Dahou AU - Mouna Lehlimi AU - Zineb Korchi AU - Rabiaa Chaini AU - Amal Badre AU - Mounir Chemsi AU - Abdelahk Habzi Y1 - 2024/04/02 PY - 2024 N1 - https://doi.org/10.11648/j.ajp.20241001.16 DO - 10.11648/j.ajp.20241001.16 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 34 EP - 40 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20241001.16 AB - Early-onset sepsis (EOS) is a worldwide major cause of morbidity and mortality especially in developing countries. The objectifs of our studie is to estimate the frequency of EOS, explore the different risk factors, the clinical features, the hematological; inflammatory and bacteriological parameters necessary for diagnosis, different causative organisms and ATB susceptibility in EOS. A 10-year retrospective study was used, including 153 cases that met the inclusion criteria. Among the 8908 admissions in NICU, sepsis occurred in 2,28% of cases. The sex ratio was 2,1 (Male: 62%, Female: 38%). Chorioamnionitis occurred in 13,7% of cases, PPROM in 44,4%. Intrapartum fever was found in 7% of cases, and amniotic fluid abnormalities in 36,6%. In neonatal risk factors we found prematurity in 76,15% of cases and VLBW in 21,56%. Respiratory distress was the most common symptom at admission with 66,1%. Bacteriological exam showed a positive Blood culture in 19,6% (30) of cases. The most common organisms isolated were E. coli in 16 cases, Group B streptococcus in 11 cases, and a positive LP in only 1 case isolating E. coli. All patients admitted to the NICU suspected of sepsis had a triple antibiotherapy. In our study, sepsis was responsible for 46,4% of deaths out of which 15 died at the first day of admission. Neonatal sepsis is associated with high rate of neonatal mortality. Poor antenatal care, absence of pregnancies follow-up, prematurity and very low birth weight are risk factors associated with EOS. In order to decrease EOS incidence and improve outcome for neonates, a contribution between Neonatologists and Obstetricians is a must. VL - 10 IS - 1 ER -
Department of Neonatal Reanimation (P4), Children’s Hospital A. Harouchi, CHU Ibn Rochd, Hassan II University, Faculty of Medicine and Pharmacy of Casablanca, Casablanca, Morocco
