LMP1 Expression of Esptein Baar Virus in Pediatric Lymphomas: A 06-Year Retrospective Series in Dakar

Abdou Magib Gaye; Cherif l Mouhamed Moustapha Dia; Ibou Thiam; Gabriel Nougnignon Comlan Deguenonvo; Fabrice Senghor; Khadidiatou Dansokho; Marie Joseph Diémé-Ahouidi

doi:doi:10.11648/j.ajp.20241001.17

Research Article |

LMP1 Expression of Esptein Baar Virus in Pediatric Lymphomas: A 06-Year Retrospective Series in Dakar

Abdou Magib Gaye^*, Cherif l Mouhamed Moustapha Dia, Ibou Thiam, Gabriel Nougnignon Comlan Deguenonvo, Fabrice Senghor, Khadidiatou Dansokho, Marie Joseph Diémé-Ahouidi

Published in American Journal of Pediatrics (Volume 10, Issue 1)

Received: 8 February 2024 Accepted: 11 March 2024 Published: 2 April 2024

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Abstract

Persistent Epstein Baar Virus (EBV) infection may be a perfect target for the treatment of EBV-associated lymphomas and improved patient outcomes. The aim of this work was to evaluate the frequency of LMP1 (Latence membrane Protein 1) expression in pediatric lymphomas in Dakar. Material and Methods: This was a retrospective, descriptive study from January 1, 2015 to December 31, 2020. It was based on blocks and anatomopathological reports of pediatric Lymphomas in 04 ACP laboratories in Dakar. The immunohistochemical study was carried out at the IBN ROCHD Hospital in Casablanca, Morocco, using a manual method. LMP1 immunostaining was considered positive if 10% of tumour cells showed cytoplasmic staining. Results: Positive staining for LMP1 was noted in 13 of the 42 cases of pediatric lymphomas tested, i.e. 31% of cases. These included 09 cases of Hodgkin's lymphoma, i.e. 69% (9/13), and 04 cases of non-Hodgkin's lymphoma, i.e. 31%. LMP1-positive classical Hodgkin's lymphomas accounted for 40.09% (9/22) of Hodgkin's lymphomas, and were of the mixed cellularity (6/22) and scleronodular (3/22) subtypes. The frequency of LMP1-positive samples in non-Hodgkin's lymphomas was 20% (4/20). These included 3 cases of Burkitt's lymphoma and 1 case of diffuse large B-cell lymphoma. Conclusion: The frequency of EBV infection in pediatric lymphomas in Senegal is lower than in endemic areas of Africa.

Published in	American Journal of Pediatrics (Volume 10, Issue 1)
DOI	10.11648/j.ajp.20241001.17
Page(s)	41-47
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Pediatric, Lymphomas, LMP1, Dakar

References

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[9]	Engel M, Essop MF, Close P, Hartley P, Pallesen G, Sinclair-Smith C. Improved prognosis of Epstein-Barr virus associated childhood Hodgkin’s lymphoma: study of 47 South African cases. J Clin Pathol 2000; 53: 182–186. https://doi.org/10.1136/jcp.53.3.182
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[14]	Araujo I, Bittencourt AL, Barbosa HS, et al. The high frequency of EBV infection in pediatric Hodgkin lymphoma is related to the classical type in Bahia, Brazil. Virchows Arch. 2006; 449(3): 315-9. https://doi.org/10.1007/s00428-006-0244-z
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APA Style

Gaye, A. M., Dia, C. L. M. M., Thiam, I., Deguenonvo, G. N. C., Senghor, F., et al. (2024). LMP1 Expression of Esptein Baar Virus in Pediatric Lymphomas: A 06-Year Retrospective Series in Dakar. American Journal of Pediatrics, 10(1), 41-47. https://doi.org/10.11648/j.ajp.20241001.17

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ACS Style

Gaye, A. M.; Dia, C. L. M. M.; Thiam, I.; Deguenonvo, G. N. C.; Senghor, F., et al. LMP1 Expression of Esptein Baar Virus in Pediatric Lymphomas: A 06-Year Retrospective Series in Dakar. Am. J. Pediatr. 2024, 10(1), 41-47. doi: 10.11648/j.ajp.20241001.17

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AMA Style

Gaye AM, Dia CLMM, Thiam I, Deguenonvo GNC, Senghor F, et al. LMP1 Expression of Esptein Baar Virus in Pediatric Lymphomas: A 06-Year Retrospective Series in Dakar. Am J Pediatr. 2024;10(1):41-47. doi: 10.11648/j.ajp.20241001.17

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@article{10.11648/j.ajp.20241001.17,
  author = {Abdou Magib Gaye and Cherif l Mouhamed Moustapha Dia and Ibou Thiam and Gabriel Nougnignon Comlan Deguenonvo and Fabrice Senghor and Khadidiatou Dansokho and Marie Joseph Diémé-Ahouidi},
  title = {LMP1 Expression of Esptein Baar Virus in Pediatric Lymphomas: A 06-Year Retrospective Series in Dakar},
  journal = {American Journal of Pediatrics},
  volume = {10},
  number = {1},
  pages = {41-47},
  doi = {10.11648/j.ajp.20241001.17},
  url = {https://doi.org/10.11648/j.ajp.20241001.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20241001.17},
  abstract = {Persistent Epstein Baar Virus (EBV) infection may be a perfect target for the treatment of EBV-associated lymphomas and improved patient outcomes. The aim of this work was to evaluate the frequency of LMP1 (Latence membrane Protein 1) expression in pediatric lymphomas in Dakar. Material and Methods: This was a retrospective, descriptive study from January 1, 2015 to December 31, 2020. It was based on blocks and anatomopathological reports of pediatric Lymphomas in 04 ACP laboratories in Dakar. The immunohistochemical study was carried out at the IBN ROCHD Hospital in Casablanca, Morocco, using a manual method. LMP1 immunostaining was considered positive if 10% of tumour cells showed cytoplasmic staining. Results: Positive staining for LMP1 was noted in 13 of the 42 cases of pediatric lymphomas tested, i.e. 31% of cases. These included 09 cases of Hodgkin's lymphoma, i.e. 69% (9/13), and 04 cases of non-Hodgkin's lymphoma, i.e. 31%. LMP1-positive classical Hodgkin's lymphomas accounted for 40.09% (9/22) of Hodgkin's lymphomas, and were of the mixed cellularity (6/22) and scleronodular (3/22) subtypes. The frequency of LMP1-positive samples in non-Hodgkin's lymphomas was 20% (4/20). These included 3 cases of Burkitt's lymphoma and 1 case of diffuse large B-cell lymphoma. Conclusion: The frequency of EBV infection in pediatric lymphomas in Senegal is lower than in endemic areas of Africa.},
 year = {2024}
}

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TY  - JOUR
T1  - LMP1 Expression of Esptein Baar Virus in Pediatric Lymphomas: A 06-Year Retrospective Series in Dakar
AU  - Abdou Magib Gaye
AU  - Cherif l Mouhamed Moustapha Dia
AU  - Ibou Thiam
AU  - Gabriel Nougnignon Comlan Deguenonvo
AU  - Fabrice Senghor
AU  - Khadidiatou Dansokho
AU  - Marie Joseph Diémé-Ahouidi
Y1  - 2024/04/02
PY  - 2024
N1  - https://doi.org/10.11648/j.ajp.20241001.17
DO  - 10.11648/j.ajp.20241001.17
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 41
EP  - 47
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20241001.17
AB  - Persistent Epstein Baar Virus (EBV) infection may be a perfect target for the treatment of EBV-associated lymphomas and improved patient outcomes. The aim of this work was to evaluate the frequency of LMP1 (Latence membrane Protein 1) expression in pediatric lymphomas in Dakar. Material and Methods: This was a retrospective, descriptive study from January 1, 2015 to December 31, 2020. It was based on blocks and anatomopathological reports of pediatric Lymphomas in 04 ACP laboratories in Dakar. The immunohistochemical study was carried out at the IBN ROCHD Hospital in Casablanca, Morocco, using a manual method. LMP1 immunostaining was considered positive if 10% of tumour cells showed cytoplasmic staining. Results: Positive staining for LMP1 was noted in 13 of the 42 cases of pediatric lymphomas tested, i.e. 31% of cases. These included 09 cases of Hodgkin's lymphoma, i.e. 69% (9/13), and 04 cases of non-Hodgkin's lymphoma, i.e. 31%. LMP1-positive classical Hodgkin's lymphomas accounted for 40.09% (9/22) of Hodgkin's lymphomas, and were of the mixed cellularity (6/22) and scleronodular (3/22) subtypes. The frequency of LMP1-positive samples in non-Hodgkin's lymphomas was 20% (4/20). These included 3 cases of Burkitt's lymphoma and 1 case of diffuse large B-cell lymphoma. Conclusion: The frequency of EBV infection in pediatric lymphomas in Senegal is lower than in endemic areas of Africa.
VL  - 10
IS  - 1
ER  -

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Author Information

Abdou Magib Gaye

Anatomical Pathology Laboratory, Hospital Aristide Le Dantec, Dakar, Senegal

Contact Email
Cherif l Mouhamed Moustapha Dia

Anatomical Pathology Laboratory, Idrissa POUYE General Hospital, Dakar, Senegal
Ibou Thiam

Anatomical Pathology Laboratory, Hospital Aristide Le Dantec, Dakar, Senegal
Gabriel Nougnignon Comlan Deguenonvo

Anatomical Pathology Laboratory, Idrissa POUYE General Hospital, Dakar, Senegal
Fabrice Senghor

Anatomical Pathology Laboratory, Hospital Aristide Le Dantec, Dakar, Senegal
Khadidiatou Dansokho

Anatomical Pathology Laboratory, Idrissa POUYE General Hospital, Dakar, Senegal
Marie Joseph Diémé-Ahouidi

Anatomical Pathology Laboratory, Fann National Hospital, Dakar, Senegal

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APA Style

Gaye, A. M., Dia, C. L. M. M., Thiam, I., Deguenonvo, G. N. C., Senghor, F., et al. (2024). LMP1 Expression of Esptein Baar Virus in Pediatric Lymphomas: A 06-Year Retrospective Series in Dakar. American Journal of Pediatrics, 10(1), 41-47. https://doi.org/10.11648/j.ajp.20241001.17

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ACS Style

Gaye, A. M.; Dia, C. L. M. M.; Thiam, I.; Deguenonvo, G. N. C.; Senghor, F., et al. LMP1 Expression of Esptein Baar Virus in Pediatric Lymphomas: A 06-Year Retrospective Series in Dakar. Am. J. Pediatr. 2024, 10(1), 41-47. doi: 10.11648/j.ajp.20241001.17

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AMA Style

Gaye AM, Dia CLMM, Thiam I, Deguenonvo GNC, Senghor F, et al. LMP1 Expression of Esptein Baar Virus in Pediatric Lymphomas: A 06-Year Retrospective Series in Dakar. Am J Pediatr. 2024;10(1):41-47. doi: 10.11648/j.ajp.20241001.17

Copy | Download

@article{10.11648/j.ajp.20241001.17,
  author = {Abdou Magib Gaye and Cherif l Mouhamed Moustapha Dia and Ibou Thiam and Gabriel Nougnignon Comlan Deguenonvo and Fabrice Senghor and Khadidiatou Dansokho and Marie Joseph Diémé-Ahouidi},
  title = {LMP1 Expression of Esptein Baar Virus in Pediatric Lymphomas: A 06-Year Retrospective Series in Dakar},
  journal = {American Journal of Pediatrics},
  volume = {10},
  number = {1},
  pages = {41-47},
  doi = {10.11648/j.ajp.20241001.17},
  url = {https://doi.org/10.11648/j.ajp.20241001.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20241001.17},
  abstract = {Persistent Epstein Baar Virus (EBV) infection may be a perfect target for the treatment of EBV-associated lymphomas and improved patient outcomes. The aim of this work was to evaluate the frequency of LMP1 (Latence membrane Protein 1) expression in pediatric lymphomas in Dakar. Material and Methods: This was a retrospective, descriptive study from January 1, 2015 to December 31, 2020. It was based on blocks and anatomopathological reports of pediatric Lymphomas in 04 ACP laboratories in Dakar. The immunohistochemical study was carried out at the IBN ROCHD Hospital in Casablanca, Morocco, using a manual method. LMP1 immunostaining was considered positive if 10% of tumour cells showed cytoplasmic staining. Results: Positive staining for LMP1 was noted in 13 of the 42 cases of pediatric lymphomas tested, i.e. 31% of cases. These included 09 cases of Hodgkin's lymphoma, i.e. 69% (9/13), and 04 cases of non-Hodgkin's lymphoma, i.e. 31%. LMP1-positive classical Hodgkin's lymphomas accounted for 40.09% (9/22) of Hodgkin's lymphomas, and were of the mixed cellularity (6/22) and scleronodular (3/22) subtypes. The frequency of LMP1-positive samples in non-Hodgkin's lymphomas was 20% (4/20). These included 3 cases of Burkitt's lymphoma and 1 case of diffuse large B-cell lymphoma. Conclusion: The frequency of EBV infection in pediatric lymphomas in Senegal is lower than in endemic areas of Africa.},
 year = {2024}
}

Copy | Download

TY  - JOUR
T1  - LMP1 Expression of Esptein Baar Virus in Pediatric Lymphomas: A 06-Year Retrospective Series in Dakar
AU  - Abdou Magib Gaye
AU  - Cherif l Mouhamed Moustapha Dia
AU  - Ibou Thiam
AU  - Gabriel Nougnignon Comlan Deguenonvo
AU  - Fabrice Senghor
AU  - Khadidiatou Dansokho
AU  - Marie Joseph Diémé-Ahouidi
Y1  - 2024/04/02
PY  - 2024
N1  - https://doi.org/10.11648/j.ajp.20241001.17
DO  - 10.11648/j.ajp.20241001.17
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 41
EP  - 47
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20241001.17
AB  - Persistent Epstein Baar Virus (EBV) infection may be a perfect target for the treatment of EBV-associated lymphomas and improved patient outcomes. The aim of this work was to evaluate the frequency of LMP1 (Latence membrane Protein 1) expression in pediatric lymphomas in Dakar. Material and Methods: This was a retrospective, descriptive study from January 1, 2015 to December 31, 2020. It was based on blocks and anatomopathological reports of pediatric Lymphomas in 04 ACP laboratories in Dakar. The immunohistochemical study was carried out at the IBN ROCHD Hospital in Casablanca, Morocco, using a manual method. LMP1 immunostaining was considered positive if 10% of tumour cells showed cytoplasmic staining. Results: Positive staining for LMP1 was noted in 13 of the 42 cases of pediatric lymphomas tested, i.e. 31% of cases. These included 09 cases of Hodgkin's lymphoma, i.e. 69% (9/13), and 04 cases of non-Hodgkin's lymphoma, i.e. 31%. LMP1-positive classical Hodgkin's lymphomas accounted for 40.09% (9/22) of Hodgkin's lymphomas, and were of the mixed cellularity (6/22) and scleronodular (3/22) subtypes. The frequency of LMP1-positive samples in non-Hodgkin's lymphomas was 20% (4/20). These included 3 cases of Burkitt's lymphoma and 1 case of diffuse large B-cell lymphoma. Conclusion: The frequency of EBV infection in pediatric lymphomas in Senegal is lower than in endemic areas of Africa.
VL  - 10
IS  - 1
ER  -

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