The Relationship Between Perioperative Blood Product Use and the Incidence of Postoperative Renal Injury in Infants Undergoing Cardiac Surgery

Yuan Yuan

doi:doi:10.11648/j.ajp.20241002.18

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The Relationship Between Perioperative Blood Product Use and the Incidence of Postoperative Renal Injury in Infants Undergoing Cardiac Surgery

Yuan Yuan^*

Published in American Journal of Pediatrics (Volume 10, Issue 2)

Received: 19 May 2024 Accepted: 5 June 2024 Published: 19 June 2024

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Abstract

Cardiac Surgery Associated Acute Kidney Injury (CS-AKI) is a serious complication that occurs in patients following cardiac surgery. It is characterized by the rapid decline in kidney function, leading to potential long-term kidney damage or even kidney failure. CS-AKI is a significant health concern, as it not only prolongs hospital stays and recovery time but also increases the risk of mortality. This study, conducted as a prospective observational study, aimed to investigate the relationship between perioperative blood product use and the incidence of postoperative acute kidney injury (AKI) in infants and young children undergoing cardiac surgery. It examined the perioperative use of these blood products and its association with the occurrence of AKI. The findings of this study revealed a significant association between the use of red blood cell suspension and platelets and the development of postoperative AKI. This suggests that the administration of these blood products during cardiac surgery may increase the risk of kidney injury in infants and young children. However, it is important to note that the study did not find a statistically significant association between plasma transfusion volume and the incidence of AKI. This suggests that while the use of certain blood products may contribute to the risk of AKI, the volume of plasma transfused does not seem to have a significant impact. The findings of this study provide valuable insights into the perioperative management of infants and young children undergoing cardiac surgery. It underscores the importance of carefully considering the use of blood products during surgery and taking necessary measures to minimize the risk of AKI.

Published in	American Journal of Pediatrics (Volume 10, Issue 2)
DOI	10.11648/j.ajp.20241002.18
Page(s)	107-111
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Cardiac Surgery, Postoperative Hemorrhage, Acute Kidney Injury

References

[1]	Hu J, Chen R, Liu S, Yu X, Zou J, Ding X. Global Incidence and Outcomes of Adult Patients With Acute Kidney Injury After Cardiac Surgery: A Systematic Review and Meta-Analysis. J Cardiothorac Vasc Anesth. 2016 Jan; 30(1): 82-9. https://doi.org/10.1053/j.jvca.2015.06.017
[2]	ALABBAS A, CAMPBELL A, SKIPPEN P, et al. Epidemiology of cardiac surgery-associated acute kidney injury in neonates: a retrospective study. Pediatr Nephrol. 2013 Jul; 28(7): 1127-34. https://doi.org/10.1007/s00467-013-2454-3
[3]	Van den Eynde J, Rotbi H, Gewillig M,, et al. In-Hospital Outcomes of Acute Kidney Injury After Pediatric Cardiac Surgery: A Meta-Analysis. Front Pediatr. 2021 Sep 3;9: 733744. https://doi.org/10.3389/fped.2021.733744
[4]	HESSEY E, MELHEM N, ALOBAIDI R, et al. Acute Kidney Injury in Critically Ill Children Is Not all Acute: Lessons Over the Last 5 Years [J]. 021 Mar 15; 9: 648587. https://doi.org/10.3389/fped.2021.648587
[5]	Djordjević A, Šušak S, Velicki L, Antonič M. ACUTE KIDNEY INJURY AFTER OPEN-HEART SURGERY PROCEDURES. Acta Clin Croat. 2021 Mar; 60(1): 120-126. https://doi.org/10.20471/acc.2021.60.01.17
[6]	Lannemyr L, Bragadottir G, Krumbholz V, et al. Effects of Cardiopulmonary Bypass on Renal Perfusion, Filtration, and Oxygenation in Patients Undergoing Cardiac Surgery. Anesthesiology. 2017 Feb; 126(2): 205-213. https://doi.org/10.1097/ALN.0000000000001461
[7]	AKCAN-ARIKAN A, ZAPPITELLI M, LOFTIS L L, et al. Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney Int. 2007 May; 71(10): 1028-35. https://doi.org/10.1038/sj.ki.5002231
[8]	Tanyildiz M, Ekim M, Kendirli T, et al. Acute kidney injury in congenital cardiac surgery: Pediatric risk-injury-failure-loss-end-stage renal disease and Acute Kidney Injury Network. Pediatr Int. 2017 Dec; 59(12): 1252-1260. https://doi.org/10.1111/ped.13359
[9]	De Souza VC, Rabilloud M, Cochat P, et al. Schwartz formula: is one k-coefficient adequate for all children? PLoS One. 2012; 7(12): e53439. https://doi.org/10.1371/journal.pone.0053439 Epub 2012 Dec 28.
[10]	Newcomb AE, Dignan R, McElduff P, et al. Bleeding After Cardiac Surgery Is Associated With an Increase in the Total Cost of the Hospital Stay. Ann Thorac Surg. 2020 Apr; 109(4): 1069-1078. https://doi.org/10.1016/j.athoracsur.2019.11.019
[11]	Rasmussen SR, Kandler K, Nielsen RV, et al. Association between transfusion of blood products and acute kidney injury following cardiac surgery. Acta Anaesthesiol Scand. 2020 Nov; 64(10): 1397-1404. https://doi.org/10.1111/aas.13664 Epub 2020 Jul 14.
[12]	Snyder-Ramos SA, Möhnle P, Weng YS, Böttiger BW, et al. The ongoing variability in blood transfusion practices in cardiac surgery. Transfusion. 2008 Jul; 48(7): 1284-99. https://doi.org/10.1111/j.1537-2995.2008.01666.x
[13]	McGrath T, Koch CG, Xu M, et al. Platelet transfusion in cardiac surgery does not confer increased risk for adverse morbid outcomes. Ann Thorac Surg. 2008 Aug; 86(2): 543-53. https://doi.org/10.1016/j.athoracsur.2008.04.051
[14]	Parreiras VC, Rocha Ide S, Martins AS, et al. Influence of fresh frozen plasma as a trigger factor for kidney dysfunction in cardiovascular surgery. Rev Bras Cir Cardiovasc. 2012 Jul-Sep; 27(3): 405-10. https://doi.org/10.5935/1678-9741.20120069
[15]	Ranucci M, Baryshnikova E, Castelvecchio S, Pelissero G; Surgical and Clinical Outcome Research (SCORE) Group. Major bleeding, transfusions, and anemia: the deadly triad of cardiac surgery. Ann Thorac Surg. 2013 Aug; 96(2): 478-85. https://doi.org/10.1016/j.athoracsur.2013.03.015
[16]	de Somer F, Mulholland JW, Bryan MR, et al. O₂ delivery and CO₂ production during cardiopulmonary bypass as determinants of acute kidney injury: time for a goal-directed perfusion management? Crit Care. 2011 Aug 10; 15(4): R192. https://doi.org/10.1186/cc10349
[17]	Karkouti K, Grocott HP, Hall R, J, et al. Interrelationship of preoperative anemia, intraoperative anemia, and red blood cell transfusion as potentially modifiable risk factors for acute kidney injury in cardiac surgery: a historical multicentre cohort study. Can J Anaesth. 2015 Apr; 62(4): 377-84. https://doi.org/10.1007/s12630-014-0302-y

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APA Style

Yuan, Y. (2024). The Relationship Between Perioperative Blood Product Use and the Incidence of Postoperative Renal Injury in Infants Undergoing Cardiac Surgery. American Journal of Pediatrics, 10(2), 107-111. https://doi.org/10.11648/j.ajp.20241002.18

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ACS Style

Yuan, Y. The Relationship Between Perioperative Blood Product Use and the Incidence of Postoperative Renal Injury in Infants Undergoing Cardiac Surgery. Am. J. Pediatr. 2024, 10(2), 107-111. doi: 10.11648/j.ajp.20241002.18

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AMA Style

Yuan Y. The Relationship Between Perioperative Blood Product Use and the Incidence of Postoperative Renal Injury in Infants Undergoing Cardiac Surgery. Am J Pediatr. 2024;10(2):107-111. doi: 10.11648/j.ajp.20241002.18

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@article{10.11648/j.ajp.20241002.18,
  author = {Yuan Yuan},
  title = {The Relationship Between Perioperative Blood Product Use and the Incidence of Postoperative Renal Injury in Infants Undergoing Cardiac Surgery
},
  journal = {American Journal of Pediatrics},
  volume = {10},
  number = {2},
  pages = {107-111},
  doi = {10.11648/j.ajp.20241002.18},
  url = {https://doi.org/10.11648/j.ajp.20241002.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20241002.18},
  abstract = {Cardiac Surgery Associated Acute Kidney Injury (CS-AKI) is a serious complication that occurs in patients following cardiac surgery. It is characterized by the rapid decline in kidney function, leading to potential long-term kidney damage or even kidney failure. CS-AKI is a significant health concern, as it not only prolongs hospital stays and recovery time but also increases the risk of mortality. This study, conducted as a prospective observational study, aimed to investigate the relationship between perioperative blood product use and the incidence of postoperative acute kidney injury (AKI) in infants and young children undergoing cardiac surgery. It examined the perioperative use of these blood products and its association with the occurrence of AKI. The findings of this study revealed a significant association between the use of red blood cell suspension and platelets and the development of postoperative AKI. This suggests that the administration of these blood products during cardiac surgery may increase the risk of kidney injury in infants and young children. However, it is important to note that the study did not find a statistically significant association between plasma transfusion volume and the incidence of AKI. This suggests that while the use of certain blood products may contribute to the risk of AKI, the volume of plasma transfused does not seem to have a significant impact. The findings of this study provide valuable insights into the perioperative management of infants and young children undergoing cardiac surgery. It underscores the importance of carefully considering the use of blood products during surgery and taking necessary measures to minimize the risk of AKI.
},
 year = {2024}
}

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TY  - JOUR
T1  - The Relationship Between Perioperative Blood Product Use and the Incidence of Postoperative Renal Injury in Infants Undergoing Cardiac Surgery

AU  - Yuan Yuan
Y1  - 2024/06/19
PY  - 2024
N1  - https://doi.org/10.11648/j.ajp.20241002.18
DO  - 10.11648/j.ajp.20241002.18
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 107
EP  - 111
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20241002.18
AB  - Cardiac Surgery Associated Acute Kidney Injury (CS-AKI) is a serious complication that occurs in patients following cardiac surgery. It is characterized by the rapid decline in kidney function, leading to potential long-term kidney damage or even kidney failure. CS-AKI is a significant health concern, as it not only prolongs hospital stays and recovery time but also increases the risk of mortality. This study, conducted as a prospective observational study, aimed to investigate the relationship between perioperative blood product use and the incidence of postoperative acute kidney injury (AKI) in infants and young children undergoing cardiac surgery. It examined the perioperative use of these blood products and its association with the occurrence of AKI. The findings of this study revealed a significant association between the use of red blood cell suspension and platelets and the development of postoperative AKI. This suggests that the administration of these blood products during cardiac surgery may increase the risk of kidney injury in infants and young children. However, it is important to note that the study did not find a statistically significant association between plasma transfusion volume and the incidence of AKI. This suggests that while the use of certain blood products may contribute to the risk of AKI, the volume of plasma transfused does not seem to have a significant impact. The findings of this study provide valuable insights into the perioperative management of infants and young children undergoing cardiac surgery. It underscores the importance of carefully considering the use of blood products during surgery and taking necessary measures to minimize the risk of AKI.

VL  - 10
IS  - 2
ER  -

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Author Information

Yuan Yuan

Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China

Contact Email

http://orcid.org/0000-0002-6883-1754

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APA Style

Yuan, Y. (2024). The Relationship Between Perioperative Blood Product Use and the Incidence of Postoperative Renal Injury in Infants Undergoing Cardiac Surgery. American Journal of Pediatrics, 10(2), 107-111. https://doi.org/10.11648/j.ajp.20241002.18

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ACS Style

Yuan, Y. The Relationship Between Perioperative Blood Product Use and the Incidence of Postoperative Renal Injury in Infants Undergoing Cardiac Surgery. Am. J. Pediatr. 2024, 10(2), 107-111. doi: 10.11648/j.ajp.20241002.18

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AMA Style

Yuan Y. The Relationship Between Perioperative Blood Product Use and the Incidence of Postoperative Renal Injury in Infants Undergoing Cardiac Surgery. Am J Pediatr. 2024;10(2):107-111. doi: 10.11648/j.ajp.20241002.18

Copy | Download

@article{10.11648/j.ajp.20241002.18,
  author = {Yuan Yuan},
  title = {The Relationship Between Perioperative Blood Product Use and the Incidence of Postoperative Renal Injury in Infants Undergoing Cardiac Surgery
},
  journal = {American Journal of Pediatrics},
  volume = {10},
  number = {2},
  pages = {107-111},
  doi = {10.11648/j.ajp.20241002.18},
  url = {https://doi.org/10.11648/j.ajp.20241002.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20241002.18},
  abstract = {Cardiac Surgery Associated Acute Kidney Injury (CS-AKI) is a serious complication that occurs in patients following cardiac surgery. It is characterized by the rapid decline in kidney function, leading to potential long-term kidney damage or even kidney failure. CS-AKI is a significant health concern, as it not only prolongs hospital stays and recovery time but also increases the risk of mortality. This study, conducted as a prospective observational study, aimed to investigate the relationship between perioperative blood product use and the incidence of postoperative acute kidney injury (AKI) in infants and young children undergoing cardiac surgery. It examined the perioperative use of these blood products and its association with the occurrence of AKI. The findings of this study revealed a significant association between the use of red blood cell suspension and platelets and the development of postoperative AKI. This suggests that the administration of these blood products during cardiac surgery may increase the risk of kidney injury in infants and young children. However, it is important to note that the study did not find a statistically significant association between plasma transfusion volume and the incidence of AKI. This suggests that while the use of certain blood products may contribute to the risk of AKI, the volume of plasma transfused does not seem to have a significant impact. The findings of this study provide valuable insights into the perioperative management of infants and young children undergoing cardiac surgery. It underscores the importance of carefully considering the use of blood products during surgery and taking necessary measures to minimize the risk of AKI.
},
 year = {2024}
}

Copy | Download

TY  - JOUR
T1  - The Relationship Between Perioperative Blood Product Use and the Incidence of Postoperative Renal Injury in Infants Undergoing Cardiac Surgery

AU  - Yuan Yuan
Y1  - 2024/06/19
PY  - 2024
N1  - https://doi.org/10.11648/j.ajp.20241002.18
DO  - 10.11648/j.ajp.20241002.18
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 107
EP  - 111
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20241002.18
AB  - Cardiac Surgery Associated Acute Kidney Injury (CS-AKI) is a serious complication that occurs in patients following cardiac surgery. It is characterized by the rapid decline in kidney function, leading to potential long-term kidney damage or even kidney failure. CS-AKI is a significant health concern, as it not only prolongs hospital stays and recovery time but also increases the risk of mortality. This study, conducted as a prospective observational study, aimed to investigate the relationship between perioperative blood product use and the incidence of postoperative acute kidney injury (AKI) in infants and young children undergoing cardiac surgery. It examined the perioperative use of these blood products and its association with the occurrence of AKI. The findings of this study revealed a significant association between the use of red blood cell suspension and platelets and the development of postoperative AKI. This suggests that the administration of these blood products during cardiac surgery may increase the risk of kidney injury in infants and young children. However, it is important to note that the study did not find a statistically significant association between plasma transfusion volume and the incidence of AKI. This suggests that while the use of certain blood products may contribute to the risk of AKI, the volume of plasma transfused does not seem to have a significant impact. The findings of this study provide valuable insights into the perioperative management of infants and young children undergoing cardiac surgery. It underscores the importance of carefully considering the use of blood products during surgery and taking necessary measures to minimize the risk of AKI.

VL  - 10
IS  - 2
ER  -

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